182182-31-6 | Exatecan Intermediate| Exatecan Intermediate: Properties, Uses and Applications
The chemical compound 182182-31-6, also known as Exatecan intermediate, is a key component in the synthesis of a drug used for the treatment of different types of cancer. This article explores the properties, uses, and applications of this important chemical compound.
Chemical Properties of 182182-31-6
182182-31-6 is a pale yellow solid substance and belongs to the family of organic compounds known as quinoline alkaloids. It has a molecular weight of 471.524 g/mol and a melting point of 148-149 degrees Celsius.
Applications of 182182-31-6
182182-31-6 is mainly used as an intermediate in the synthesis of various compounds, especially the synthesis of Exatecan mesylate, which is a cytotoxic anticancer drug belonging to the non-camptothecin family of topoisomerase I inhibitors. This intermediate is a vital component in the synthesis of drugs used to treat ovarian cancer, colon cancer, and other types of solid tumors.
Synthesis of Exatecan Mesylate
Exatecan Mesylate, also known as DX-8951f, is used to treat a variety of malignant tumors. It is synthesized from 182182-31-6 through a multi-step process that involves several chemical reactions. At each stage, the product is purified to remove impurities and obtain the intermediate product, which is used in the next reaction step.
Drug Formulation
Exatecan Mesylate is formulated as a sterile lyophilized powder and is administered through injection. The exact dosage and protocol depend on the patient, the cancer type, and other factors. It works by inhibiting DNA topoisomerase I and, thus, interfering with DNA synthesis and repair, eventually leading to the cancer cell's death.
Side Effects
Exatecan Mesylate is a potent cytotoxic agent that affects both normal and cancer cells. As such, it has many potential side effects, which may include nausea, vomiting, hair loss, fatigue, low blood cell count, fever, and others. Patients taking Exatecan Mesylate are closely monitored to identify any adverse reactions.
Toxicity
The toxicity of 182182-31-6 varies depending on the exposure level and duration. In general, it is considered harmful when ingested or inhaled in high concentrations. Exposure to 182182-31-6 can lead to respiratory problems, skin irritation, and other health issues. As such, it needs to be handled with care, following the appropriate safety procedures and guidelines.
Storage
182182-31-6 should be stored in a cool, dry, and well-ventilated area. It should also be kept away from sources of ignition, heat, and direct sunlight. The compound is stable under normal conditions but may degrade when exposed to moisture or light.
Environmental Impact
The environmental impact of 182182-31-6 is not yet fully understood. As an organic compound, it may have potential effects on the environment if released into the soil or water supplies. However, the compound's impact is likely to be minimal, given its low toxicity and relatively low usage levels.
Regulations
182182-31-6 is not considered a controlled substance by most countries, but it may be subject to different regulatory standards in various jurisdictions. As such, users and suppliers are advised to follow the relevant guidelines and regulations to ensure the safe handling and use of the compound.
Summary
182182-31-6 is a key intermediate in the synthesis of Exatecan Mesylate, a potent cytotoxic anticancer drug used to treat a variety of tumors. It has many potential applications in the pharmaceutical industry and is an essential building block for many other compounds. While it has some toxicity and environmental impact concerns, it is generally considered safe when handled correctly and following appropriate regulations and guidelines.