2212021-83-3 - Orforglipron intermediate: A Comprehensive Guide
If you are working in the pharmaceutical industry or any related field, there’s a good chance that you’ve come across the term "2212021-83-3 - Orforglipron intermediate". This term refers to a key intermediate compound that is used in the synthesis of Orforglipron, an important drug used in diabetes treatment. In this article, we will take a closer look at this compound and its significance in the production of Orforglipron.
What is Orforglipron?
Orforglipron is a drug that belongs to the class of thiazolidinediones, which are used to treat type 2 diabetes. The drug works by improving the body's response to insulin and lowering blood sugar levels. Orforglipron has been found to be effective in reducing the risk of cardiovascular disease in diabetic patients. The synthesis of Orforglipron involves several steps, and 2212021-83-3 is a key intermediate compound in this process.
What is 2212021-83-3?
2212021-83-3 is a chemical compound that is used in the synthesis of Orforglipron. It is a white to pale yellow powder that is soluble in organic solvents such as dimethyl sulfoxide and methanol. It has a molecular weight of 281.33 g/mol and a molecular formula of C12H11NO4S.
Significance of 2212021-83-3 in Orforglipron Synthesis
2212021-83-3 is a key intermediate compound in the synthesis of Orforglipron. It is used in the process of converting the starting material, which is 3-bromo-4-fluorobenzaldehyde, into the final product, Orforglipron. The compound undergoes several reactions, including a Grignard reaction and an S-alkylation reaction, which lead to the formation of Orforglipron.
Synthesis of 2212021-83-3
The synthesis of 2212021-83-3 involves several steps, starting from 2-hydroxy-phenylacetic acid. The acid is first converted into the corresponding ester, which is then subjected to bromination using N-bromosuccinimide. The resulting bromo ester undergoes a nucleophilic substitution reaction with p-fluoroaniline in the presence of potassium carbonate to form the desired product, 2212021-83-3.
Properties of 2212021-83-3
2212021-83-3 is a stable compound that is relatively easy to handle in the laboratory. It has a melting point of around 160°C and a boiling point of about 360°C. The compound is sensitive to moisture and should be stored in a dry and well-ventilated area.
Applications of 2212021-83-3
2212021-83-3 is primarily used as an intermediate compound in the synthesis of Orforglipron. However, it may also find applications in other areas such as agrochemicals and pharmaceuticals. The compound has been found to possess antimicrobial activity and could be used as a lead compound for the development of new drugs.
Safety Considerations
When working with 2212021-83-3, it is important to take the necessary safety precautions. The compound may cause skin and eye irritation and could be harmful if ingested. It should be handled in a well-ventilated area, and appropriate personal protective equipment should be worn. The compound should be stored in a secure location away from children and animals.
Conclusion
2212021-83-3 is a key intermediate compound in the synthesis of Orforglipron, an important drug used in diabetes treatment. The compound undergoes several reactions to produce the final product. It has found applications in other areas such as agrochemicals and pharmaceuticals and possesses antimicrobial activity. When handling 2212021-83-3, it is important to take the necessary safety precautions.