Introduction
CAS 142217-80-9 Entecavir intermediate is a pharmaceutical compound that is a widely used antiviral agent. It is a key intermediate in the manufacturing of the antiviral drug Entecavir, which is used to treat chronic hepatitis B infections. This article presents in-depth information on this important intermediate.
What is CAS 142217-80-9 Entecavir intermediate?
CAS 142217-80-9 Entecavir intermediate is a key building block in the synthesis of Entecavir, which is used to treat chronic hepatitis B infections. This intermediate is a white to off-white crystalline powder that is soluble in water. It is an essential component in the production of Entecavir, which is estimated to be one of the most effective antiviral drugs for treating hepatitis B.
Synthesis of CAS 142217-80-9 Entecavir intermediate
Entecavir intermediate is synthesized from ethyl-3-bromo propionate and guanine in a four-step process that involves ester hydrolysis, halogen-metal exchange, palladium-catalyzed coupling, and deprotection. This synthesis route has been optimized to produce a high yield of the intermediate with minimal side-products, making it a cost-effective and efficient process.
Applications of CAS 142217-80-9 Entecavir intermediate
The primary application of CAS 142217-80-9 Entecavir intermediate is as a starting material for the synthesis of Entecavir. The drug is widely used in the treatment of chronic hepatitis B virus infections, having been found to reduce viral replication and improve liver function. Entecavir is also used as a first-line therapy for patients with hepatitis B virus-related cirrhosis.
Properties of CAS 142217-80-9 Entecavir intermediate
CAS 142217-80-9 Entecavir intermediate has a molecular formula of C10H13N5O4 and a molecular weight of 267.24 g/mol. It has a melting point of 167-170°C and a boiling point of 540.5°C at 760 mmHg. The compound also has good solubility in water.
Storage of CAS 142217-80-9 Entecavir intermediate
CAS 142217-80-9 Entecavir intermediate should be stored in a tightly sealed container in a cool, dry place, away from light and moisture. The compound should be kept at room temperature and protected from extreme temperatures, which can cause degradation and loss of potency.
Safety and handling of CAS 142217-80-9 Entecavir intermediate
CAS 142217-80-9 Entecavir intermediate is considered to be a low hazard chemical under normal use conditions. However, like all chemicals, it should be handled with care to avoid skin and eye contact. Always wear personal protective equipment such as gloves, protective clothing, and eye protection when handling this compound.
Quality Control of CAS 142217-80-9 Entecavir intermediate
CAS 142217-80-9 Entecavir intermediate should be subjected to rigorous quality control measures to ensure its purity and potency. Typical quality control tests for this compound include analysis by high-performance liquid chromatography, infrared spectroscopy, and nuclear magnetic resonance spectroscopy.
Conclusion
CAS 142217-80-9 Entecavir intermediate is a critical intermediate in the production of Entecavir, which is widely used as an antiviral agent for the treatment of hepatitis B. This compound has a high level of purity, good solubility, and is considered to be a low hazard chemical. It is essential to ensure quality control measures are in place during its production to ensure the purity and potency of the compound.