Introduction
CAS 169869-90-3 Exatecan Mesylate is a drug used in cancer therapy. It belongs to the class of drugs called topoisomerase I inhibitors and it works by inhibiting the function of an enzyme called topoisomerase I, which is essential for DNA replication and cell proliferation. In this article, we will look at the various aspects of CAS 169869-90-3 Exatecan Mesylate.
Chemical Properties of CAS 169869-90-3 Exatecan Mesylate
CAS 169869-90-3 Exatecan Mesylate is a semi-synthetic derivative of camptothecin, which is a natural alkaloid. Its chemical formula is C31H28N2O10S and its molecular weight is 640.63 g/mol. It is a pale yellow crystalline powder that is soluble in DMSO, ethanol, and methanol.
Medical Uses of CAS 169869-90-3 Exatecan Mesylate
CAS 169869-90-3 Exatecan Mesylate is used in the treatment of various types of cancer, including ovarian cancer, lung cancer, and leukemia. It is administered through intravenous infusion and its dosage depends on the patient's weight and overall health.
Mechanism of Action of CAS 169869-90-3 Exatecan Mesylate
CAS 169869-90-3 Exatecan Mesylate works by binding to and inhibiting the activity of topoisomerase I, an enzyme that is crucial for DNA replication and cell division. By inhibiting this enzyme, the drug prevents cancer cells from dividing and growing.
Side Effects of CAS 169869-90-3 Exatecan Mesylate
Like all drugs, CAS 169869-90-3 Exatecan Mesylate has some side effects. The most common side effects include nausea, vomiting, diarrhea, fatigue, and weakness. Other less common side effects include anemia, neutropenia, thrombocytopenia, and liver toxicity.
Precautions and Contraindications
CAS 169869-90-3 Exatecan Mesylate should not be used in patients who are allergic to it or to any of its components. It should also be used with caution in patients with liver or kidney problems and in pregnant or breastfeeding women.
Drug Interactions
CAS 169869-90-3 Exatecan Mesylate can interact with various medications, such as warfarin, dexamethasone, and phenytoin. It is crucial to notify the doctor of all medications the patient is currently using prior to beginning treatment with this drug.
Storage
CAS 169869-90-3 Exatecan Mesylate should be stored in a cool, dry place, away from direct sunlight and heat. It should also be kept out of the reach of children.
Conclusion
CAS 169869-90-3 Exatecan Mesylate is a potent drug used in cancer therapy. It works by inhibiting the activity of topoisomerase I, an enzyme that is essential for DNA replication and cell division. While it is generally well-tolerated, it can cause some side effects and should be used with caution in certain patients.