Introduction
Isavuconazole CAS: 241479-73-2 is a triazole antifungal used to treat invasive aspergillosis and invasive mucormycosis. This article will explore various aspects of this keyword.
Mechanism of Action
Isavuconazole CAS: 241479-73-2 works by inhibiting the lanosterol 14-alpha-demethylase enzyme in fungi, which is essential for the biosynthesis of ergosterol, a crucial component of fungal cell membranes. This leads to the disruption of the fungal cell membrane, ultimately resulting in cell death.
Indications
Isavuconazole CAS: 241479-73-2 is indicated for the treatment of invasive aspergillosis and invasive mucormycosis in adult patients. It is also used for the treatment of candidiasis and certain other fungal infections.
Dosage and Administration
The recommended dosage of Isavuconazole CAS: 241479-73-2 for the treatment of invasive fungal infections is 372 mg (equivalent to 200 mg of the prodrug) administered orally or intravenously every 8 hours for the first 6 doses, followed by 372 mg (equivalent to 200 mg of the prodrug) administered once daily. The duration of treatment may vary depending on the type and severity of the fungal infection.
Side Effects
The most common side effects of Isavuconazole CAS: 241479-73-2 include nausea, vomiting, diarrhea, headache, fever, and skin rash. Other less common but serious side effects may include liver dysfunction, allergic reactions, and QT prolongation.
Contraindications
Isavuconazole CAS: 241479-73-2 is contraindicated in patients with known hypersensitivity to the drug or any of its components. It should also be used with caution in patients with hepatic impairment, renal impairment, and cardiac disease.
Drug Interactions
Isavuconazole CAS: 241479-73-2 may interact with several drugs such as rifampin, phenytoin, and carbamazepine, leading to decreased efficacy of Isavuconazole. It may also interact with drugs that prolong the QT interval, leading to an increased risk of arrhythmias.
Pregnancy and Lactation
There is limited data on the safety of Isavuconazole CAS: 241479-73-2 during pregnancy and lactation. However, it should be used only if the potential benefits outweigh the potential risks to the fetus or infant.
Storage
Isavuconazole CAS: 241479-73-2 should be stored at room temperature, away from light and moisture. It should be kept out of reach of children and pets.
Conclusion
Isavuconazole CAS: 241479-73-2 is a triazole antifungal used for the treatment of invasive fungal infections. It works by inhibiting the lanosterol 14-alpha-demethylase enzyme in fungi. The drug has several side effects and drug interactions, and caution should be exercised when using it in certain patient populations.