Introduction
Isavuconazole intermediate, CAS 368421-58-3, is a vital component of the antifungal medication Isavuconazonium sulfate. Isavuconazole intermediate is produced through a multi-step process that starts with the synthesis of (1R,2S)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol. This article seeks to offer an in-depth understanding of
Isavuconazole intermediate CAS 368421-58-3, its chemical properties, manufacturing process, and applications.
Chemical Properties
Isavuconazole intermediate CAS 368421-58-3 has the molecular formula C14H16F2N4O and a molecular weight of 298.303 g/mol. The compound has a purity level of at least 98%, and its appearance is a white or off-white powder. It has a melting point range between 83-88°C and is soluble in organic solvents such as chloroform, ethanol, and DMSO.
Manufacturing Process
The manufacturing process of Isavuconazole intermediate, CAS 368421-58-3, involves several steps. It starts with the synthesis of (1R,2S)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, which is then subjected to Mitsunobu coupling with isobutyric acid. The resulting product undergoes a coupling reaction with (R)-tert-butanesulfinamide, followed by deprotection to yield Isavuconazole intermediate, CAS 368421-58-3.
Applications
Isavuconazole intermediate, CAS 368421-58-3, is a vital component of the antifungal medication Isavuconazonium sulfate. The drug is used in the treatment of invasive aspergillosis and invasive mucormycosis, two life-threatening fungal infections. Isavuconazole intermediate inhibits the growth of the fungus by blocking the synthesis of ergosterol, a vital component of the fungal cell membrane.
Safety and Hazards
Isavuconazole intermediate, CAS 368421-58-3, is a stable compound and poses no significant hazards. However, like any other chemical, it is advisable to handle the compound with caution and use protective equipment such as gloves and goggles when handling it.
Storage and Handling
Isavuconazole intermediate, CAS 368421-58-3, should be stored in a cool, dry, and well-ventilated area away from sources of ignition, heat, and oxidizing agents. It should be handled with care and stored in air-tight containers to prevent contamination.
Costs and Availability
Isavuconazole intermediate, CAS 368421-58-3, is available from several reputable suppliers. The cost of the compound varies depending on the supplier, purity level, and quantity ordered.
Conclusion
Isavuconazole intermediate, CAS 368421-58-3, is a crucial component of the antifungal medication Isavuconazonium sulfate. The compound is synthesized through several steps and has a purity level of at least 98%. It is used in the treatment of invasive aspergillosis and invasive mucormycosis, two life-threatening fungal infections. The compound is stable and poses no significant hazards, but it should be handled with caution and stored appropriately to prevent contamination.
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