Introduction
Exatecan Mesylate, also known as DX-8951, is a synthetic derivative of camptothecin, an alkaloid obtained from the bark of the Chinese tree Camptotheca acuminata. Exatecan Mesylate is a potent DNA topoisomerase I inhibitor, which means it can halt or slow down the replication of cancer cells. In this article, we will talk about the various aspects of CAS 169869-90-3 Exatecan Mesylate.
Properties of Exatecan Mesylate
Exatecan Mesylate has a molecular formula of C30H32ClN3O8S and a molecular weight of 647.11 g/mol. It is a light yellow powder that is soluble in water, methanol, and ethanol but insoluble in ethyl acetate and dichloromethane.
Uses of Exatecan Mesylate
Exatecan Mesylate has potential uses in cancer treatment. It has been shown to be effective against various types of cancer, including breast cancer, lung cancer, ovarian cancer, and pancreatic cancer. Additionally, it has been tested in clinical trials as a treatment for refractory and relapsed solid tumors.
Mechanism of Action
As mentioned before, Exatecan Mesylate works by inhibiting DNA topoisomerase I, an enzyme that is essential for DNA replication. When the cell tries to copy itself, topoisomerase I relieves tension in the DNA so that it can be unwound, copied, and then rewound. Without this activity, the DNA strands cannot be separated, and replication cannot occur, leading to cell death.
Storage
Exatecan Mesylate should be stored in a cool, dry place at room temperature and protected from light. It should be stored away from any heat sources or strong oxidizing agents.
Preparation and Administration
Exatecan Mesylate is available as a sterile lyophilized powder for injection. It should be prepared and administered only by a licensed healthcare provider with experience in handling chemotherapy drugs. The appropriate dosage and treatment schedule will depend on various factors, including the patient's medical history, age, weight, and the type and stage of cancer.
Alternative Names
Exatecan Mesylate is also known as DX-8951, LCK-893, and SJG-136.
Conclusion
In conclusion, Exatecan Mesylate is a potent chemotherapy drug that is being explored as a potential treatment option for various types of cancer. Its mechanism of action and efficacy against solid tumors make it a promising drug in the fight against cancer.